Study finds women’s negative moods can cause cardiovascular disease

MINNEAPOLIS Healthy middle-aged women with feelings of hopelessness appear to experience thickening of the neck arteries, which can be a precursor to stroke, according to new research out of the University of Minnesota Medical School.

The study, published online last week in Stroke: Journal of the American Heart Association, found that hopelessness — negative thinking and feelings of uselessness — affects arteries independent of clinical depression and before women develop clinically relevant cardiovascular disease.

Researchers looked at 559 women (average age 50, 62% white, 38% African-American) who were generally healthy and did not show signs of clinical cardiovascular disease.

The study found a consistent, progressive and linear association between increasing neck artery thickness and rising levels of hopelessness. The overall difference in arterial thickening between women with higher versus lower hopelessness scores, about .02 mm, was equal to about one year of thickening. Those with the highest hopelessness scores had an average .06 mm greater thickening than those in the lowest group — a clinically significant difference. This correlation remained after adjusting for any influence of age, race, income, cardiovascular risk factors and depression.

“Previous studies have shown that hopelessness is associated with cardiovascular disease outcomes in men and also in women with documented heart disease. However, this is the first study to suggest that hopelessness may be related to subclinical cardiovascular disease in women without clinical symptoms of heart disease and who are generally healthy,” stated Susan Everson-Rose, principal investigator of the study and associate director of the Program in Health Disparities Research.

“These findings suggest that women who experience feelings of hopelessness may have greater risk for future heart disease and stroke,” Everson-Rose said. “In fact, our data indicate that hopelessness may be uniquely related to cardiovascular disease risk. We did not see similar relations when looking at global depressive symptoms.”