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Study: Higher doses of Vitamin D reduce bone fractures in seniors

3/24/2009

CHICAGO A meta-analysis published Monday in the "Archives of Internal Medicine" determined that higher doses of vitamin D supplementation, of more than 400 International Units daily, could reduce the number of fractures in seniors by at least 20%.

The meta-analysis was performed on the efficacy of oral supplemental vitamin D in preventing nonvertebral and hip fractures among older individuals, and included 12 double-blind randomized controlled trials for nonvertebral fractures and 8 RCTs for hip fractures comparing oral vitamin D, with or without calcium, with calcium or placebo.

The higher dose reduced nonvertebral fractures in community-dwelling individuals by 29% and institutionalized older individuals by 15%, and its effect was independent of additional calcium supplementation.

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