Study: Moms who get flu shot while pregnant provide significant protection to newborn

SALT LAKE CITY - Babies whose moms get flu vaccinations while pregnant have a significantly reduced risk of acquiring influenza during their first six months of life, a new study shows, leading the authors to declare that the need for getting more pregnant women immunized is a public health priority.

 

In a study published May 3, 2016, in Pediatrics online, University of Utah School of Medicine researchers reported that infants 6 months and younger whose mothers were vaccinated when pregnant had a 70% reduction in laboratory-confirmed flu cases and an 80% reduction in flu-related hospitalizations compared with babies whose moms weren't immunized. Health records showed that 97% of laboratory-confirmed flu cases occurred in infants whose mom's were not immunized against the disease while pregnant.

 

"Babies cannot be immunized during their first six months, so they must rely on others for protection from the flu during that time," stated Julie Shakib, assistant professor of pediatrics and lead author. "When pregnant women get the flu vaccine there are clear benefits for their infants."

 

Maternal-fetal medicine specialist Michael Varner, professor and vice chair for research in the Department of Obstetrics and Gynecology and a co-author on the study, says pregnant women are not at greater risk for getting the flu, but because of changes that occur to their bodies during pregnancy, are more likely to be severely affected.

 

Shakib and colleagues examined more than 245,000 de-identified health records of pregnant women and more than 249,000 infant records for nine flu seasons from December 2005 through March 2014. (The number of infant births included twins, triplets or even larger sets of babies, which accounts for the total number of infant birth records being greater than the number of records of pregnant women.) Approximately 10% of the women - 23,383 - reported being vaccinated while pregnant compared with 222,003 who said they were not vaccinated.

 

The difference between the two groups in the number of laboratory-confirmed influenza cases and influenza hospitalizations within six months of birth was stark, the researchers found. Among 658 infants identified with laboratory-confirmed influenza, 638 cases - 97% - occurred in babies whose moms were not immunized. A total of 151 of the 658 infants were hospitalized, with 148 being born to non-immunized pregnant women.

 

In order to confirm that the benefits observed in infants born to mothers who received flu vaccinations were not related to chance, the researchers also examined health records for the incidence of respiratory syncytial virus, a respiratory infection that also occurs in infants and young children during the winter months. The analysis found that the vaccine had no effect on the incidence of RSV among infants, strengthening the findings that the benefits seen in the infants were actually due to the flu vaccine their mothers received.

 

Although the vaccination rate among pregnant women has increased since the H1N1 pandemic, it's still not high enough, according to infectious diseases expert Carrie Byington, senior author on the study, professor of pediatrics and co-director of the Center for Clinical and Translational Science at the University of Utah Health Sciences, which provided support for the study.

 

"This is a public health issue," Byington said. "About 50% of pregnant women reported being immunized in the latest flu season. But we need to get that number much closer to 100%."

 

Vaccination rates in pregnant women averaged 10% over the course of the nine flue seasons studied. However, between June 2009 and September 2010, when the spread of the H1N1 flu reached pandemic levels worldwide, vaccination rates increased significantly as people became more aware of the risks of flu for pregnant women and their infants. "Pregnant women are a high-risk group during influenza season and influenza outbreaks and should receive vaccinations," Varner said. "If their caregivers don't offer them influenza vaccinations, I would encourage all pregnant women to ask them for it."

 

"We just really hope more pregnant women get the vaccine," Shakib added. "That's the take-home message of the study."