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With medication nonadherence leading to enormous health complications for millions of Americans — and generating staggering and needless cost spikes that add as much as $290 billion a year to the nation’s healthcare costs — the search for ways to get patients to take their prescription medicines as directed has become increasingly urgent.

Here’s a fact that keeps health plan administrators and anyone else responsible for budgeting health costs awake at night: 1-in-5 hospital patients ends up back in the hospital within 30 days of their discharge. And the biggest factors pulling them back all have to do with medications — either through medication errors, nonadherence or adverse drug events.