Over the past 75 years, Lewis Drug has come to epitomize the best of regional drug store retailing. Based in Sioux Falls, S.D., the company has become deeply embedded in the life of many Upper Midwest communities, and the go-to resource for pharmacy and front-line healthcare services in dozens of towns scattered throughout eastern South Dakota, Minnesota and northwest Iowa. Its largest stores wield a remarkably wide assortment of products and generate in excess of $10 million annually.